Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide-Alkyne Cycloaddition Reactions

• Main Authors: Matt Timmers (Author), Andi Kipper (Author), Raphael Frey (Author), Stef Notermans (Author), Maksym Voievudskyi (Author), Claire Wilson (Author), Nina Hentzen (Author), Michael Ringle (Author), Clara Bovino (Author), Bernhard Stump (Author), Cristianne J. F. Rijcken (Author), Tina Vermonden (Author), Ingrid Dijkgraaf (Author), Rob Liskamp (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide-alkyne cycloaddition (SPAAC), metal-free click chemistry. This research explores the properties of TMTHSI-based compounds via three aspects: (1) la...