Granzyme B PET Imaging in Response to In Situ Vaccine Therapy Combined with αPD1 in a Murine Colon Cancer Model

• Main Authors: Siddesh V. Hartimath (Author), Boominathan Ramasamy (Author), Tan Yun Xuan (Author), Tang Jun Rong (Author), Shivashankar Khanapur (Author), Peter Cheng (Author), You Yi Hwang (Author), Edward G. Robins (Author), Julian L. Goggi (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibitors (ICIs) block checkpoint receptors that tumours use for immune evasion, allowing immune cells to target and destroy cancer cells. Despite rapid advancements in immunotherapy, durable response rates to ICIs remains low. To address this, combination clinical trials are unde...