Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus

• Main Authors: Kristina Wardelmann (Author), Michaela Rath (Author), José Pedro Castro (Author), Sabine Blümel (Author), Mareike Schell (Author), Robert Hauffe (Author), Fabian Schumacher (Author), Tanina Flore (Author), Katrin Ritter (Author), Andreas Wernitz (Author), Toru Hosoi (Author), Koichiro Ozawa (Author), Burkhard Kleuser (Author), Jürgen Weiß (Author), Annette Schürmann (Author), André Kleinridders (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduc...