Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases

• Main Authors: Ryunosuke Nakashima (Author), Shunsuke Kamei (Author), Hirofumi Nohara (Author), Haruka Fujikawa (Author), Kasumi Maruta (Author), Taisei Kawakami (Author), Yuka Eto (Author), Noriki Takahashi (Author), Mary Ann Suico (Author), Toru Takeo (Author), Naomi Nakagata (Author), Hirofumi Kai (Author), Tsuyoshi Shuto (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary emphysema, inflammation and senescence-like phenotype are pathophysiological characteristics of chronic obstructive pulmonary disease (COPD). Recently, a murine model of COPD has been established by inducing airway-specific overexpression of epithelial Na+ channel β subunit (βENaC-Tg mice)...