Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer

• Main Authors: Qiumei Li (Author), Shuoran Tian (Author), Jiadi Liang (Author), Jiqiang Fan (Author), Junzhong Lai (Author), Qi Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STI...