Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

• Main Authors: Michael Shum (Author), Mayuko Segawa (Author), Raffi Gharakhanian (Author), Ana Viñuela (Author), Matthew Wortham (Author), Siyouneh Baghdasarian (Author), Dane M. Wolf (Author), Samuel B. Sereda (Author), Laura Nocito (Author), Linsey Stiles (Author), Zhiqiang Zhou (Author), Vincent Gutierrez (Author), Maike Sander (Author), Orian S. Shirihai (Author), Marc Liesa (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin resistance and T2D, demonstrating an early altera...