Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway

• Main Authors: Jiali Yang (Author), Kangjian Zhang (Author), Jing Wu (Author), Juan Shi (Author), Jing Xue (Author), Jing Li (Author), Juan Chen (Author), Yongzhao Zhu (Author), Jun Wei (Author), Jinxi He (Author), Xiaoming Liu (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migr...