Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

• Main Authors: Shin J. Lee (Author), Graciela Sanchez-Watts (Author), Jean-Philippe Krieger (Author), Angelica Pignalosa (Author), Puck N. Norell (Author), Alyssa Cortella (Author), Klaus G. Pettersen (Author), Dubravka Vrdoljak (Author), Matthew R. Hayes (Author), Scott Kanoski (Author), Wolfgang Langhans (Author), Alan G. Watts (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body weight regulation and the sympathetic control of brown adipose tissue (BAT) thermogenesis. Therefore, DMH GLP-1 receptors (GLP-1R) are well...