Analysis of DUX4 Expression in Bone Marrow and Re-Discussion of DUX4 Function in the Health and Disease

• Egile Nagusiak: Ceren HANGUL (Egilea), Oznur TOKTA (Egilea), Sibel BERKER KARAUZUM (Egilea), Bahar AKKAYA (Egilea), Hulya YILDIRIM (Egilea), Funda TAYFUN KUPESIZ (Egilea), Ayse Nur AKINEL (Egilea)
• Formatua: Liburua
• Argitaratua: Federation of Turkish Pathology Societies, 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: DUX4 is an embryonic transcription factor (TF) later silenced in somatic tissues, while active in germline testis cells. Re-expression in somatic cells has been revealed to be present in pathologic conditions such as dystrophy, leukemia, and other cancer types. Embryonic cells, cancer cel...