Analysis of DUX4 Expression in Bone Marrow and Re-Discussion of DUX4 Function in the Health and Disease

• Main Authors: Ceren HANGUL (Author), Oznur TOKTA (Author), Sibel BERKER KARAUZUM (Author), Bahar AKKAYA (Author), Hulya YILDIRIM (Author), Funda TAYFUN KUPESIZ (Author), Ayse Nur AKINEL (Author)
• Format: Book
• Published: Federation of Turkish Pathology Societies, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: DUX4 is an embryonic transcription factor (TF) later silenced in somatic tissues, while active in germline testis cells. Re-expression in somatic cells has been revealed to be present in pathologic conditions such as dystrophy, leukemia, and other cancer types. Embryonic cells, cancer cel...