A Nitrobenzoyl Sesquiterpenoid Insulicolide A Prevents Osteoclast Formation via Suppressing c-Fos-NFATc1 Signaling Pathway

• Main Authors: Yanhui Tan (Author), Minhong Ke (Author), Zhichao Li (Author), Yan Chen (Author), Jiehuang Zheng (Author), Yiyuan Wang (Author), Xuefeng Zhou (Author), Gang Huang (Author), Xiaojuan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is a viable strategy to inhibit osteoclast differentiation for the treatment of osteolytic diseases such as osteoporosis, rheumatoid arthritis and tumor bone metastases. Here we assessed the effects of insulicolide A, a natural nitrobenzoyl sesquiterpenoid derived from marine fungus, on receptor...