Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors

• Main Authors: Hong Wang (Author), Rui Guo (Author), Zhonghua Du (Author), Ling Bai (Author), Lingyu Li (Author), Jiuwei Cui (Author), Wei Li (Author), Andrew R. Hoffman (Author), Ji-Fan Hu (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene targeting, epigenetic modulation by the catalytically inactive dCas9 may also be a potential form of cancer therapy. Granulin (G...