Copanlisib population pharmacokinetics from phase I-III studies and exposure-response relationships in combination with rituximab

• Main Authors: Peter N. Morcos (Author), Jonathan Moss (Author), Rupert Austin (Author), Florian Hiemeyer (Author), Pier Luigi Zinzani (Author), Vita Beckert (Author), Lidia Mongay Soler (Author), Barrett H. Childs (Author), Dirk Garmann (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Copanlisib dose selection was established under the maximum tolerated dose paradigm, and no dedicated dose‐finding studies have investigated copanlisib dose selection when used in combination with rituximab. In CHRONOS‐3, copanlisib plus rituximab demonstrated significantly improved progres...