Inflammation Affects Liver Function and the Metabolism of Voriconazole to Voriconazole-N-Oxide in Adult and Elderly Patients

• Main Authors: Zaiming Liang (Author), Mingjie Yu (Author), Zhirui Liu (Author), Fang Liu (Author), Changsheng Jia (Author), Lirong Xiong (Author), Qing Dai (Author), Shiwei Qin (Author), Lin Cheng (Author), Fengjun Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The inner association of inflammation with voriconazole (VCZ) metabolism has not been fully investigated. We intend to investigate the effects of inflammation on liver function, VCZ trough concentration (C0), C0/dose ratio and the ratio of VCZ to VCZ-N-oxide concentration (C0/CN) in adul...