Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A₁receptor activation

• 主要な著者: Zylka Mark J (著者), Voss Meagen K (著者), Sowa Nathaniel A (著者)
• フォーマット: 図書
• 出版事項: SAGE Publishing, 2010-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesi...