Pharmaceutical Characterization and In Vivo Evaluation of Orlistat Formulations Prepared by the Supercritical Melt-Adsorption Method Using Carbon Dioxide: Effects of Mesoporous Silica Type

• Main Authors: Heejun Park (Author), Kwang-Ho Cha (Author), Seung Hyeon Hong (Author), Sharif Md Abuzar (Author), Seungyeol Lee (Author), Eun-Sol Ha (Author), Jeong-Soo Kim (Author), In-Hwan Baek (Author), Min-Soo Kim (Author), Sung-Joo Hwang (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Orlistat, an anti-obesity drug, has two critical issues-the first is its low efficacy due to low water solubility and the second is side effects such as oily spotting due to its lipase inhibition. The present study was designed to propose a solution using a formulation with mesoporous silica to simu...