Brain Targeting of Quetiapine Fumarate via Intranasal Delivery of Loaded Lipospheres: Fabrication, In-Vitro Evaluation, Optimization, and In-Vivo Assessment

• Main Authors: Randa Mohammed Zaki (Author), Mohammed F. Aldawsari (Author), Manal A. Alossaimi (Author), Shaikah F. Alzaid (Author), Vidya Devanathadesikan Seshadri (Author), Alanood S. Almurshedi (Author), Basmah Nasser Aldosari (Author), Rehab Mohammad Yusif (Author), Ossama M. Sayed (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A liposphere system for intranasal delivery of quetiapine fumarate (QTF) was created to assess the potential for enhanced drug delivery. We investigated the effects of particle size, entrapment effectiveness, poly dispersibility index, and pluronic incorporation percentage on these variables. The op...