Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma

• Main Authors: Xingliang Guo (Author), Hua Jiang (Author), Bizhi Shi (Author), Min Zhou (Author), Honghong Zhang (Author), Zhimin Shi (Author), Guoxiu Du (Author), Hong Luo (Author), Xiuqi Wu (Author), Yi Wang (Author), Ruixin Sun (Author), Zonghai Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer immunotherapy has made unprecedented breakthrough in the fields of chimeric antigen receptor-redirected T (CAR T) cell therapy and immune modulation. Combination of CAR modification and the disruption of endogenous inhibitory immune checkpoints on T cells represent a promising immunotherapeut...