Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice

• Main Authors: Wan-qing Xie (Author), Yong-jian Zhao (Author), Feng Li (Author), Bing Shu (Author), Shu-ru Lin (Author), Li Sun (Author), Yong-jun Wang (Author), Hong-xin Zheng (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocyte exhibits osteoarthritis-like phenotype in the lumbar disc and knee j...