Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

• Main Authors: Daniel Margerie (Author), Philippe Lefebvre (Author), Violeta Raverdy (Author), Uwe Schwahn (Author), Hartmut Ruetten (Author), Philip Larsen (Author), Alain Duhamel (Author), Julien Labreuche (Author), Dorothée Thuillier (Author), Bruno Derudas (Author), Céline Gheeraert (Author), Hélène Dehondt (Author), Quentin Dhalluin (Author), Jérémy Alexandre (Author), Robert Caiazzo (Author), Pamela Nesslany (Author), Helene Verkindt (Author), François Pattou (Author), Bart Staels (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecular mechanisms however are unknown. Methods An obser...