Design, synthesis and antitumor activities of fluoroquinolone C-3 heterocycles (IV): s-triazole Schiff-Mannich bases derived from ofloxacin

• المؤلفون الرئيسيون: Guoqiang Hu (مؤلف), Guoqiang Wang (مؤلف), Nannan Duan (مؤلف), Xiaoyi Wen (مؤلف), Tieyao Cao (مؤلف), Songqiang Xie (مؤلف), Wenlong Huang (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2012-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction of a heterocyclic ring as a bioisostere of the C-3 carboxylic acid group. To this end, two series of eleven s-triazole derivatives bearing functionalized side chains of Schiff bases an...