Design, synthesis and antitumor activities of fluoroquinolone C-3 heterocycles (IV): s-triazole Schiff-Mannich bases derived from ofloxacin

• Main Authors: Guoqiang Hu (Author), Guoqiang Wang (Author), Nannan Duan (Author), Xiaoyi Wen (Author), Tieyao Cao (Author), Songqiang Xie (Author), Wenlong Huang (Author)
• Format: Book
• Published: Elsevier, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction of a heterocyclic ring as a bioisostere of the C-3 carboxylic acid group. To this end, two series of eleven s-triazole derivatives bearing functionalized side chains of Schiff bases an...