Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry

• Main Authors: Qihong Zhang (Author), Nikolay E. Polyakov (Author), Yulia S. Chistyachenko (Author), Mikhail V. Khvostov (Author), Tatjana S. Frolova (Author), Tatjana G. Tolstikova (Author), Alexandr V. Dushkin (Author), Weike Su (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na2GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na2GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scanning...