Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry

• Principais autores: Qihong Zhang (Autor), Nikolay E. Polyakov (Autor), Yulia S. Chistyachenko (Autor), Mikhail V. Khvostov (Autor), Tatjana S. Frolova (Autor), Tatjana G. Tolstikova (Autor), Alexandr V. Dushkin (Autor), Weike Su (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na2GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na2GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scanning...