Long-Term Effects of Biliverdin Reductase a Deficiency in <i>Ugt1</i>^−/− Mice: Impact on Redox Status and Metabolism

• Main Authors: Giulia Bortolussi (Author), Xiaoxia Shi (Author), Lysbeth ten Bloemendaal (Author), Bhaswati Banerjee (Author), Dirk R. De Waart (Author), Gabriele Baj (Author), Weiyu Chen (Author), Ronald P. Oude Elferink (Author), Ulrich Beuers (Author), Coen C. Paulusma (Author), Roland Stocker (Author), Andrés F. Muro (Author), Piter J. Bosma (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and prevent neurotoxicity in neonatal and adult settings seem promising....