Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents

• Main Authors: Fei Liu (Author), Qin Wan (Author), Pengfei Liu (Author), Dengshun Miao (Author), Xiuliang Dai (Author), Li Chen (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chemical agents such as alkylating agents (AAs) that are commonly used for the treatment of cancer cause great damage to the ovaries, thereby significantly increasing the risk of premature ovarian insufficiency (POI). However, the exact molecules underlying AA-induced POI remain...