4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line

• Main Authors: Polyana Lopes Benfica (Author), Renato Ivan de Ávila (Author), Bruna dos Santos Rodrigues (Author), Alane Pereira Cortez (Author), Aline Carvalho Batista (Author), Marilisa Pedroso Nogueira Gaeti (Author), Eliana Martins Lima (Author), Kênnia Rocha Rezende (Author), Marize Campos Valadares (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: 4-Nerolidylcatechol (4-NRC) has showed antitumor potential through apoptosis. However, its apoptotic mechanisms are still unclear, especially in leukemic cells. Objectives: To evaluate the cytotoxic potential of 4-NRC and its cell death pathways in p53-null K562 leukemic cells. Materials an...