A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon

• Main Authors: Erin R Burnight (Author), Janice M Staber (Author), Pavel Korsakov (Author), Xianghong Li (Author), Benjamin T Brett (Author), Todd E Scheetz (Author), Nancy L Craig (Author), Paul B McCray, Jr (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonviral vector systems are used increasingly in gene targeting and gene transfer applications. The piggyBac transposon represents an alternative integrating vector for in vivo gene transfer. We hypothesized that this system could achieve persistent gene transfer to the liver when administered syste...