Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing

• Main Authors: Hua Yang (Author), Keyun Qing (Author), Geoffrey D. Keeler (Author), Ling Yin (Author), Mario Mietzsch (Author), Chen Ling (Author), Brad E. Hoffman (Author), Mavis Agbandje-McKenna (Author), Mengqun Tan (Author), Wei Wang (Author), Arun Srivastava (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that of the 10 most commonly used adeno-associated virus (AAV) serotype vectors, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs) in vitro, as well as in vivo. More recently, polyvinyl alcohol (PVA), was reported to be a superior replacement fo...