Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis

• Main Authors: Hanna Niehues (Author), Gijs Rikken (Author), Ivonne M.J.J. van Vlijmen-Willems (Author), Diana Rodijk-Olthuis (Author), Piet E.J. van Erp (Author), Patrick L.J.M. Zeeuwen (Author), Joost Schalkwijk (Author), Ellen H. van den Bogaard (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia). The milieu of disease-associated cytokines and soluble factors is considered a mitogenic factor; however, pinpointing the exact mitogen...