Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

• Main Authors: Fuhua Wang (Author), Huan Wang (Author), Xuejing Liu (Author), Haiyi Yu (Author), Bo Zuo (Author), Zhu Song (Author), Ning Wang (Author), Wei Huang (Author), Guisong Wang (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postconditioning (IP). Methods We used a myocardial reperfusion injury rat m...