Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2

• Main Authors: Rena G. Lapidus (Author), Brandon A. Carter-Cooper (Author), Mariola Sadowska (Author), Eun Yong Choi (Author), Omasiri Wonodi (Author), Nidal Muvarak (Author), Karthika Natarajan (Author), Lakshmi S. Pidugu (Author), Anil Jaiswal (Author), Eric A. Toth (Author), Feyruz V. Rassool (Author), Arash Etemadi (Author), Edward A. Sausville (Author), Maria R. Baer (Author), Ashkan Emadi (Author)
• Format: Book
• Published: MDPI AG, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel anti-leukemic chemotherapeutics with potential applications in the treatment of acute myeloid leukemia (AML), a molecularly heterogeneous disease. Dim...