Insulin regulates human pancreatic endocrine cell differentiation in vitro

• Main Authors: Perla Cota (Author), Özüm Sehnaz Caliskan (Author), Aimée Bastidas-Ponce (Author), Changying Jing (Author), Jessica Jaki (Author), Lama Saber (Author), Oliver Czarnecki (Author), Damla Taskin (Author), Anna Karolina Blöchinger (Author), Thomas Kurth (Author), Michael Sterr (Author), Ingo Burtscher (Author), Natalie Krahmer (Author), Heiko Lickert (Author), Mostafa Bakhti (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The consequences of mutations in genes associated with monogenic forms of diabetes on human pancreas development cannot be studied in a time-resolved fashion in vivo. More specifically, if recessive mutations in the insulin gene influence human pancreatic endocrine lineage formation is st...