Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development

• Main Authors: Djordje Medarević (Author), Jelena Djuriš (Author), Panagiotis Barmpalexis (Author), Kyriakos Kachrimanis (Author), Svetlana Ibrić (Author)
• Format: Bog
• Udgivet: MDPI AG, 2019-08-01T00:00:00Z.
• Fag: article
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The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer solubility and miscibility. Only if the drug concentration is below the solubility limit in the polymer, the physical...