Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against <i>Trypanosoma cruzi</i>: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against <i>Trypanosoma cruzi</i>: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic countries. The available drugs, benznidazole (Bz) and nifurtimox, have limited effectiveness and intense side effects. Drug repurposing, and the deve...

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Main Authors: Leonardo da Silva Lara (Author), Guilherme Curty Lechuga (Author), Lorraine Martins Rocha Orlando (Author), Byanca Silva Ferreira (Author), Bernardo Araújo Souto (Author), Maurício Silva dos Santos (Author), Mirian Claudia de Souza Pereira (Author)
Format: Book
Published: MDPI AG, 2022-05-01T00:00:00Z.
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3rd Floor Main Library

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