Current status and future promise of next-generation poly (ADP-Ribose) polymerase 1-selective inhibitor AZD5305

• প্রধান লেখক: Jingcao Zheng (লেখক), Zhengyu Li (লেখক), Wenjiao Min (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The family of poly (ADP-ribose) polymerases (PARPs) consists of 17 members, which have been demonstrated as having effects on a series of cellular processes, including DNA replication and repair. PARP inhibitors (PARPi) suppress DNA repair through "PARP trapping", thus, constitute an impor...