Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

• Main Authors: Maxime Annereau (Author), Marina Vignes (Author), Lucas Denis (Author), André Rieutord (Author), François-Xavier Legrand (Author), François Rioblanc (Author), Muriel Paul (Author), Jacques Grill (Author), Philippe-Henri Secretan (Author), Bernard Do (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma is one of the most common and aggressive forms of brain tumor, a rare disease for which there is a great need for innovative therapies. ONC201, a new drug substance, has been used in a compassionate treatment program where the choice of dosage form and regimen have yet to be justified....