Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

• Main Authors: Lee Moir (Author), Elena G. Bochukova (Author), Rebecca Dumbell (Author), Gareth Banks (Author), Rasneer S. Bains (Author), Patrick M. Nolan (Author), Cheryl Scudamore (Author), Michelle Simon (Author), Kimberly A. Watson (Author), Julia Keogh (Author), Elana Henning (Author), Audrey Hendricks (Author), Stephen O'Rahilly (Author), Inês Barroso (Author), Adrienne E. Sullivan (Author), David C. Bersten (Author), Murray L. Whitelaw (Author), Susan Kirsch (Author), Elizabeth Bentley (Author), I. Sadaf Farooqi (Author), Roger D. Cox (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. Methods: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-e...