On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition

• Main Authors: Xiaoqing Liu (Author), Shuang Liang (Author), Xiao Sang (Author), Lili Chang (Author), Shunli Fu (Author), Han Yang (Author), Huizhen Yang (Author), Yongjun Liu (Author), Na Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer immunotherapy has become a promising strategy. However, the effectiveness of immunotherapy is restricted in "cold tumors" characterized with insufficient T cells intratumoral infiltration and failed T cells priming. Herein, an on-demand integrated nano-engager (JOT-Lip) was develope...