Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity

• Autors principals: Shuai Zhang (Autor), Tingting Wang (Autor), Ye Feng (Autor), Fei Li (Autor), Aijuan Qu (Autor), Xiuchen Guan (Autor), Hui Wang (Autor), Dan Xu (Autor)
• Format: Llibre
• Publicat: Elsevier, 2023-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme (CYP), which plays a crucial role in the metabolism of neurosteroids. The antiepileptic drug phenytoin (PHT) has been observed to induce neuronal side effects in patients...