Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

• Main Authors: Jie Zheng (Author), Shanshan Hu (Author), Jinxin Wang (Author), Xulan Zhang (Author), Ding Yuan (Author), Changcheng Zhang (Author), Chaoqi Liu (Author), Ting Wang (Author), Zhiyong Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and anti-aging. Objective To evaluate the effect of ICA on natural aging rat. Materials and methods 16-month-old Sprague-Dawley (SD) r...