Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice

• Автори: Mohammad Suhail Khan (Автор), Virginie Jakob (Автор), Randhir Singh (Автор), Raju S. Rajmani (Автор), Sahil Kumar (Автор), Céline Lemoine (Автор), Harry Kleanthous (Автор), Rajesh P. Ringe (Автор), Patrice M. Dubois (Автор), Raghavan Varadarajan (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor binding domain retains immunogenicity and pro...