Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice

• Main Authors: Mohammad Suhail Khan (Author), Virginie Jakob (Author), Randhir Singh (Author), Raju S. Rajmani (Author), Sahil Kumar (Author), Céline Lemoine (Author), Harry Kleanthous (Author), Rajesh P. Ringe (Author), Patrice M. Dubois (Author), Raghavan Varadarajan (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor binding domain retains immunogenicity and pro...