Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

• Main Authors: Takuya Kikuchi (Author), Kana Orihara (Author), Fusaka Oikawa (Author), Song-iee Han (Author), Motoko Kuba (Author), Kanako Okuda (Author), Aoi Satoh (Author), Yoshinori Osaki (Author), Yoshinori Takeuchi (Author), Yuichi Aita (Author), Takashi Matsuzaka (Author), Hitoshi Iwasaki (Author), Shigeru Yatoh (Author), Motohiro Sekiya (Author), Naoya Yahagi (Author), Hiroaki Suzuki (Author), Hirohito Sone (Author), Yoshimi Nakagawa (Author), Nobuhiro Yamada (Author), Hitoshi Shimano (Author)
• Format: Book
• Published: Elsevier, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The transcription factor cyclic AMP-responsive element-binding protein H (CREBH, encoded by Creb3l3) is highly expressed in the liver and small intestine. Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression. However...