Delivery Pathway Regulation of 3',3"-Bis-Peptide-siRNA Conjugate via Nanocarrier Architecture Engineering

• Egile Nagusiak: Jing Sun (Egilea), Chong Qiu (Egilea), Yiping Diao (Egilea), Wei Wei (Egilea), Hongwei Jin (Egilea), Yi Zheng (Egilea), Jiancheng Wang (Egilea), Lihe Zhang (Egilea), Zhenjun Yang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Small interfering RNA (siRNA) has been continuously explored for clinical applications. However, neither nanocarriers nor conjugates have been able to remove the obstacles. In this study, we employed a combined nanochemistry strategy to optimize its delivery dilemma, where different interactions and...