Glucocorticoids mediate transcriptome‐wide alternative polyadenylation: Potential mechanistic and clinical implications

• Main Authors: Thanh Thanh L. Nguyen (Author), Duan Liu (Author), Huanyao Gao (Author), Zhenqing Ye (Author), Jeong‐Heon Lee (Author), Lixuan Wei (Author), Jia Yu (Author), Lingxin Zhang (Author), Liewei Wang (Author), Tamas Ordog (Author), Richard M. Weinshilboum (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Alternative polyadenylation (APA) is a common genetic regulatory mechanism that generates distinct 3' ends for RNA transcripts. Changes in APA have been associated with multiple biological processes and disease phenotypes. However, the role of hormones and their drug analogs in APA rem...