In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

• Main Authors: Georgia Melagraki (Author), Evangelos Ntougkos (Author), Dimitra Papadopoulou (Author), Vagelis Rinotas (Author), Georgios Leonis (Author), Eleni Douni (Author), Antreas Afantitis (Author), George Kollias (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many ch...