IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10

• Main Authors: Xin Fang (Author), Leilei Guo (Author), Zikang Xing (Author), Lei Shi (Author), Heng Liang (Author), Aiying Li (Author), Chunxiang Kuang (Author), Bangbao Tao (Author), Qing Yang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in tryptophan catabolism along the kynurenine (Kyn) pathway and exerts immunosuppressive properties mainly via activation of transcription factor aryl hydrocarbon receptor (AhR) pathway. IDO1 induces NK cells dysfunction via downr...