The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

• Main Authors: Luiza S. E. P. Will Castro (Author), Wietske Pieters (Author), Mir Farshid Alemdehy (Author), Muhammad A. Aslam (Author), Olimpia Alessandra Buoninfante (Author), Jonne A. Raaijmakers (Author), Bas Pilzecker (Author), Paul C. M. van den Berk (Author), Hein te Riele (Author), René H. Medema (Author), Rozangela C. Pedrosa (Author), Heinz Jacobs (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. This...