Pseudolaric Acid B-Induced Autophagy Contributes to Senescence via Enhancement of ROS Generation and Mitochondrial Dysfunction in Murine Fibrosarcoma L929 Cells

• Main Authors: Min Qi (Author), Simiao Fan (Author), Guodong Yao (Author), Zhao Li (Author), Haiyan Zhou (Author), Shin-ichi Tashiro (Author), Satoshi Onodera (Author), Mingyu Xia (Author), Takashi Ikejima (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pseudolaric acid B (PAB) is the primary biologically active compound isolated from the root bark of P. kaempferi Gordon. Our previous study demonstrated that PAB induced mitotic catastrophe in L929 cells and indicated that only a small percentage (12%) of the cells undergoing mitotic catastrophe dis...