Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model

• Main Authors: Imke Rudnik-Jansen (Author), Karin Schrijver (Author), Nina Woike (Author), Anna Tellegen (Author), Sabine Versteeg (Author), Pieter Emans (Author), George Mihov (Author), Jens Thies (Author), Niels Eijkelkamp (Author), Marianna Tryfonidou (Author), Laura Creemers (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based local TAA release may prolong the suppression of pain...