Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

• Main Authors: Ying Zhi (Author), Kerui Fan (Author), Shuang Liu (Author), Kai Hu (Author), Xinyan Zan (Author), Ling Lin (Author), Yongqiang Yang (Author), Xianqiong Gong (Author), Kun Chen (Author), Li Tang (Author), Longjiang Li (Author), Jiayi Huang (Author), Shujun Zhang (Author), Li Zhang (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Enhanced glycolysis is a crucial metabolic event that drives the development of liver fibrosis, but the molecular mechanisms have not been fully understood. Lactate is the endproduct of glycolysis, which has recently been identified as a bioactive metabolite binding to G-protein-...