Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

• Main Authors: Qingqing Wu (Author), Huijuan Zhu (Author), Rong Song (Author), Mengqi Zhang (Author), Fangqiong Li (Author), Weifang Zeng (Author), Wei Wang (Author), Jingying Jia (Author), Chen Yu (Author), Yanmei Liu (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese subjects. An open‐label, two‐period crossove...