Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate

• Ngā kaituhi matua: Josimar Oliveira Eloy (Author), Juliana Saraiva (Author), Sérgio de Albuquerque (Author), Juliana Maldonado Marchetti (Author)
• Hōputu: Pukapuka
• I whakaputaina: Universidade de São Paulo, 2015-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growi...